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BACTERIAL,
VIRALS AND OTHERS
NEGLECTED TROPICAL DISEASES

WHAT WE DO?

Bacterial, Viral and other Neglected Tropical Diseases are among the main causes of morbidity and mortality causing a diversity of clinical syndromes, constituting a problem for public health in the country. Among these, we highlight those caused by pathogens associated with enteric, acute respiratory infections and invasive bacterial diseases that affect mainly children under 5 years of age. In 2015, there were, globally, around 5.8 million deaths in children in this age group, where pneumonia, diarrhea and sepsis/meningitis were among the top 5 causes of death, contributing with 920,000 (15%), 526,000 (9.1%) and 517,000 (8.9%) deaths, respectively. In Mozambique, results of verbal autopsy indicated pneumonia, diarrhea and malnutrition as being among the top 5 causes of death in children under 15 years of age.

 

On the other hand, diseases caused by viruses other than HIV, have occupied a prominent place in public health due to their distribution and high prevalence, particularly in children under 5 years of age. Although there are programs and efforts to mitigate them, challenges regarding early diagnosis and treatment, scarcity of data on weight and circulating strains prevail, especially for viruses associated with respiratory infections.

 

Due to the high prevalence and impact of Neglected Tropical Diseases (NTDs) in the country, especially in rural areas where the prevalence exceeds 40%, control strategies have been 

implemented following WHO and UNICEF recommendations, which include the massive administration of medicines, control of morbidity, improvement of water conditions, sanitation and hygiene, as well as education towards health.

Main objectives

  • Continue to contribute to the definition of disease weight by monitoring epidemiological trends and circulating strains to guide the development of control and prevention tools at local, national and international levels

  • Contribute to the development, testing and evaluation of the impact of intervention tools (e.g. vaccines, drugs, new screening and diagnostic methods, etc.)

  • Understand the dynamics of disease transmission, driving research on emerging diseases and the one health approach (zoonotic and emerging diseases)

  • Establish new approaches to molecular research in the context of antimicrobial resistance, transmission patterns and virulence of major pathogens

  • Contribute to the training of new staff at different levels and specialties.

 
 

TEAM

Inacio

Ignatius Commanding

Coordinator

Dr. Inácio Mandomando holds a PhD in Biomedical Sciences (Microbiology) from the University of Barcelona, Spain (2009), and has an international scientific background that has more than 100 publications, his main area of research being diarrheal diseases, and other invasive bacterial diseases in Mozambique. Dr. Mandomando was selected in 2013 as Senior Researcher at CISM and was Deputy Scientific Director (2013-2016) and is currently Coordinator of the Diarrheal Disease Research Area and Principal Investigator of the CHAMPS project in Mozambique.

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PROJECTS

 
  • A CA. Assessment of Access to Drinking Water in the District of Manhiça

  • ECOHEMA. Study of the coinfection between helminths and malaria and its implication in the immune response against malaria

  • GBS MULTI. Group B Streptococcus colonization in mother-newborn dyads and association with anti-capsular serotype-specific antibodies in low and middle income South Asian and African countries

  • iNTS. Non-typhoid salmonella carriage in a Mozambican district with high HIV prevalence

  • LPOS. Low Pressure Oxygen

  • MARS. Design and implementation of a baseline surveillance and monitoring platform for the emergence of anthelmintic resistance in the district of Manhiça

  • PERS. Pertussis and Respiratory Syncytial Virus in Pregnancy

  • PLUS. Evaluation of the impact of lung ultrasound on management of pneumonia in low-resource settings, and feasibility, usability and acceptability of this technology

  • Pneumo- PCV. Impact assessment of the introduction of the pneumococcal vaccine in Mozambique

  • Pneumo-PCV-2. Assessment of the additional impact of switching from PCV-10 vaccine to PCV-13

  • BREATHE. Respiratory Syncytial virus (RSV) Infection in Pregnant Women and Children in Rural Southern Mozambique: Determining the incidence of disease associated mortality and risks factors

  • ROUTE. Surveillance of Rotavirus and other enteropathogens in children under 05 years old in Manhiça district

  • WASH. Water supply, sanitation and hygiene conditions in Manhiça district and its association with soil-transmitted helminths and schistosomes infection.

  • WASH-IT. Evaluation of the effect of a water, sanitation and hygiene intervention on the soil-transmitted helminth re-infection in schoolchildren in Manhiça district.

Other ongoing projects

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PUBLICATIONS

Area still under construction

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